De-risk your clinical development

inClude

Building on Volv Global`s inTrigue capability, inClude is an advanced way of building computational models using machine learning to detect difficult to diagnose, and reveal the degree of heterogeneity, at the level of patients phenotypes and predictable course of disease, in population-scale databases such as electronic health records.

With at the heart of it, the core predictive modeling make up of the inTrigue methodology, inClude is designed to enrich new disease insights and learnings, delivering value specifically to strategically inform and de-risk clinical drug development activities, and help operationalise clinical trial programs more effectively and efficiently.

What is inClude

Be empowered to de-risk and differentiate your clinical development

Using robust proprietary technology we focus on difficult-to-diagnose conditions, to generate comprehensive knowledge of disease, that helps you to de-risk and differentiate your drug development efforts. With inClude, it is possible to identify your target patient population precisely and consider both diagnosed and yet undiagnosed target patient populations. From identification of patients earlier in disease progression, you can reveal novel Biomarkers and develop differentiating Outcome Assessments

What is inClude

Tangible patient-centricity

inClude learns robust prediction models that characterise undiagnosed and misdiagnosed patient cohorts for difficult to diagnose diseases with a very high accuracy, revealing the natural history of the full target patient population, not just of those already diagnosed.
inClude reveals the heterogeneity in your full target patient population, and allows you to incorporate this in your clinical development strategy, design and execution:


• Manage heterogeneity risks
• Develop differentiating endpoints, in earlier disease states
• Select lead candidate drug based on newly discovered biomarkers
• Align trial operations around newly identified patients


Identifying the right target patient population for
clinical development by characterising patients,
using real world evidence in a new way.

1

Uniquely capturing the population heterogeneity

inClude reveals the heterogeneity in the population and allows you to define more precisely the disease characteristics and spectrum of unmet medical needs around which to design your clinical development plan.

2

Considering all the patients, diagnosed and undiagnosed

inClude, allows you to tap into the full potential of the diseased population, diagnosed and undiagnosed, enabling you to reduce your operational risk and more.

3

Defining the target patient population more accurately

inClude captures the unknown heterogeneity of the population and defines your target patient population precisely and accurately and increase the chance of clinical success.

4

Understanding the disease pathway much earlier

inClude identifies new patient cohorts in earlier stages of disease, and helps you better understand these early disease pathways.

5

Discovering biomarkers that are completely novel

inClude can bring into focus novel biomarkers that unlock the key for better understanding disease biology.

6

Redefining clinical outcome assessments around the patients

By typically allowing identification of people living with disease much earlier in their journey, inClude opens the door for defining new and earlier Clinical Outcome Assessments.